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Two medicines. Two cessation stories. One sequence that will not pick a villain.

Use this page to hold differences without turning them into slogans.

Antidepressants

Stopping is often a staged event

Many antidepressants require planned dose reduction because discontinuation symptoms can occur. Relapse and withdrawal can resemble one another. This site will not write a taper.

Discontinuation explainer

ADHD stimulants

Cessation is commonly managed differently

Some therapeutic stimulant regimens can often be ceased differently from antidepressants. Rebound still happens. Non-stimulants are not in this comparison. “ADHD medication can always just be stopped tomorrow” is a sentence this site refuses.

Stimulant cessation

What caused the change?

A fictional month. Step through it. Then try to name a single cause.

Antidepressant stable

Continue through the weeks. Do not skip to a verdict.

Evidence methods, compared by the question they answer

MethodAnswers
Personal observationWhat happened to this person, and when?
Qualitative researchWhat does the experience feel like, in language people actually use?
Survey dataWhat do groups of people report, with all the biases of who answers?
Observational studyWhat associations appear across records, without random assignment?
Clinical trialDoes treatment outperform comparison on average, under trial conditions?
Systematic reviewWhat does the trial literature look like when studies are put together?
GuidelineWhat do appointed reviewers currently recommend in practice?
PharmacovigilanceWhat unusual events are being reported, without a reliable denominator?